B03 Systematic understanding and realization of hyper-adaptive phenomena focusing on cognition and emotion

Research Outline

Mainly from the viewpoint of reorganization of the behavioral rules of the hyper-adaptability mechanism, methods are developed for verifying a hypothesis that emotion and sense of agency promote the behavioral emergence, which was set in this study. In stroke, cognitive motor function is lost due to brain circuit failure. Rehabilitation that is therapy aiming at restoring cognitive motor function, is considered as a hyper-adaptive process in which new motor functions is reorganized by making full use of the brain nervous system and musculoskeletal system that were not used in healthy condition, even though it is difficult to recover the brain nervous system completely to the state before onset. In this study, focusing on rehabilitation, the mechanism of hyper-adaptability is investigated from a systematical approach, and new rehabilitation methods are developed based on the investigation with verifying the hypothesis mentioned above.

In concrete, robotic interventional neuroscience platforms for humans and experimental animals (monkeys, rodents) are developed, and the effects of emotion and cognition on the reorganization of behavioral rules are investigated by using the platforms. By using the brain information decoding method that can estimate the function, the effects of emotion and cognition on motor learning are quantitatively investigated, analyzed, and modeled mathematically. Moreover, by applying the investigated findings, quantitative measurement and mathematical modeling of the hyper-adaptability process observed at the rehabilitation site are made, and based on this, new rehabilitation methods that can effectively promote the potential adaptability (hyper-adaptability) of the brain are developed and verified.

Members

Principal investigator	Hajime ASAMA	Professor, The University of Tokyo
Funded co-investigator	Jun IZAWA	Associate Professor, University of Tsukuba
	Qi AN	Associate Professor, The University of Tokyo
	Wen WEN	Associate Professor, Rikkyo University
Co-investigators	Masafumi YANO	Professor Emeritus, Tohoku University
	Atsushi YAMASHITA	Professor, Graduate School of Frontier Sciences, The University of Tokyo
	Hiroyuki HAMADA	Project Assistant Professor, The University of Tokyo
	Yukio HONDA	Project Researcher, The University of Tokyo
	Acer Chang	Assistant Professor, Rikkyo University
	Ningjia YANG	Researcher, RIKEN
	Yutaka KIKUCHI	Department Chief, Institute of Brain and Blood Vessels Mihara Memorial Hospital
	Yuta OKUDA	Institute of Brain and Blood Vessels Mihara Memorial Hospital
	Dal’Bello Lucas	Researcher, Laboratory of Neuromotor Physiology, Fondazione Santa Lucia