B04 Modelling of hyper adaptability in human postural control considering the role of neurotransmitters

Research Outline

ota
B04
Jun OTA

The study in this research group aims to verify the following hypothesis from the viewpoint of reconstitution of sensorimotor control rules of the hyper-adaptation functions: Neurotransmitters (such as dopamine; DA), whose levels are reduced in patients with neurodegenerative disorders, adjust the activity levels in various brain areas and coupling strength between neuronal circuits as well as control the multitasking function.
The term “multitasking function” denotes the ability to execute multiple tasks smoothly and simultaneously. To achieve this, we attempt to build a mathematical model that considers the role of neurotransmitters in posture control in co-operation with the A04 research group and other B01-B04 research groups. We address the study in three steps. 1) Verification of the role of neurotransmitters in posture control. The function necessary for multitasking is assumed to be impaired in patients with neurodegenerative disorders, such as Parkinson’s disease, and neuronal degeneration and abnormalities in neurotransmitters are thought to exist. To verify the role of the neurotransmitters in multitasking, we focus on neurotransmitters that may change in patients with Parkinson’s disease. 2) Development of a multitasking representation model that considers the role of neurotransmitters in posture control. A mathematical multitasking model will be developed to integrate information regarding neurotransmitters from a micro-viewpoint and information regarding behavioral and physiological reactions from a macro-viewpoint that appear to result from information processing. 3) Verification of this mathematical model using data obtained from humans.

Our project focuses on the following three specific themes. 1) Establishment of a method to evaluate the multitasking ability. Posture control with an applied cognitive load will be used as a model of multitasking. A method to evaluate the multitasking ability in healthy individuals and patients will be established. A protocol to design multitasking and measure physiological reactions during multitasking will be established. 2) Development of a multi-layer brain–physical activity integration model that comprises an appropriate network among (a) brain-activity dynamic model, (b) sensory motor-control system model, and (c) physical musculoskeletal model. 3) Verification of the built model. Data from 1) will be integrated into the model built in 2) to verify the model.
We attempt to “build a mathematical model for change in brain representation of the sensorimotor control rules considering the neurotransmitters” by performing research on the aforementioned subjects. The model proposed here is expected to provide a base for therapeutic strategies for multitasking rehabilitation.

Members

Principal investigator Jun OTA Professor, The University of Tokyo
Funded co-investigator Arito YOZU Associate Professor, The University of Tokyo
Co-investigator Shohei SHIRAFUJI Assistant Professor, The University of Tokyo
Kohei KAMINISHI Postdoctoral Fellow, The University of Tokyo
Yuichiro OMURA Master’s Student, The University of Tokyo
Daisuke ISHII Assistant Professor, Ibaraki Prefectural University of Health Sciences
Hiroyuki HAMADA Assistant, Bunkyo Gakuin University
Yutaka KOHNO Professor, Ibaraki Prefectural University of Health Sciences
Hiroshi KISHIMOTO Lecturer, Ibaraki Prefectural University of Health Sciences
Hiroshi YUINE Assistant Professor, Ibaraki Prefectural University of Health Sciences
Kiyoshige ISHIBASHI Ibaraki Prefectural University of Health Sciences
Hitohiro ETOH Undergraduate Student, The University of Tokyo
Mariko MIYATA Professor, Tokyo Women’s Medical University
Hironobu OSAKI Assistant Professor, Tokyo Women’s Medical University
Moeko KANAYA Assistant Professor, Tokyo Women’s Medical University