A01 Elucidation of the hyper-adaptation mechanism by reconstruction of bio-structure and challenges for prevention of decline in latent adaptive capacity

Research Outline

Tadashi ISA

In A01, we primarily address the hypothesis that disinhibition of global neural network underlies the reconstitution of the neural structure as a basis of hyper-adaptability. We aim to unravel the mechanism of disinhibition of the neural network through analysis of the rodent, monkey and human brains and propose an effective strategy for functional improvement based on the evidence for the age-related functional deterioration. The mechanism underlying the global disinhibition in the brain is uncovered through long-term and longitudinal analysis of neural and muscular activity in the monkeys before and after the spinal injury using electrocorticography and electromyography. Pathway-specific manipulation and recording in rodents provides the neural substrate which accounts for how the dopaminergic and serotonergic diffuse modulatory system mediate the disinhibition of the global neural networks. Functional magnetic resonance imaging study reveals chronic disinhibitory state in the aged human brain and proposes effective training methods which improves functional deterioration using age-related progress and magnitude of neural disinhibition as an indicator.


Principal investigator Tadashi ISA Professor, Kyoto University
Funded co-investigator Eiichi NAITO Research Manager, CiNet
Hideki AIZAWA Professor, Hiroshima University
Minoru ASADA Specially Appointed Professor, Osaka University
Co-investigators Hirotaka ONOE Project Professor, Kyoto University
Tomohiko TAKEI Project Associate Professor, Kyoto University
Reona YAMAGUCHI Project Assistant Professor, Kyoto University
Yusuke YAMAMOTO PhD Student, Kyoto University
Toshinari KAWASAKI PhD Student, Kyoto University
Satoko UENO PhD Student, Kyoto University
Masahiro MITSUHASHI PhD Student, Kyoto University
Tomoyo MORITA Project Associate Professor, Osaka University
Satoshi HIROSE Researcher, CiNet
Nodoka KIMURA Researcher, CiNet
Miho MATSUMATA Assistant Professor, Hiroshima University
Deepa Kamath
Assistant Professor, Hiroshima University
Takashi HANDA Assistant Professor, Hiroshima University