A01 Elucidation of the hyper-adaptation mechanism by reconstruction of bio-structure and challenges for prevention of decline in latent adaptive capacity
Research Outline
Tadashi ISA
In A01, we primarily address the hypothesis that disinhibition of global neural network underlies the reconstitution of the neural structure as a basis of hyper-adaptability. We aim to unravel the mechanism of disinhibition of the neural network through analysis of the rodent, monkey and human brains and propose an effective strategy for functional improvement based on the evidence for the age-related functional deterioration. The mechanism underlying the global disinhibition in the brain is uncovered through long-term and longitudinal analysis of neural and muscular activity in the monkeys before and after the spinal injury using electrocorticography and electromyography. Pathway-specific manipulation and recording in rodents provides the neural substrate which accounts for how the dopaminergic and serotonergic diffuse modulatory system mediate the disinhibition of the global neural networks. Functional magnetic resonance imaging study reveals chronic disinhibitory state in the aged human brain and proposes effective training methods which improves functional deterioration using age-related progress and magnitude of neural disinhibition as an indicator.
Members
| Principal investigator | Tadashi ISA | Professor, Kyoto University |
| Funded co-investigator | Eiichi NAITO | Director, CiNet |
| Hidenori AIZAWA | Professor, Hiroshima University | |
| Minoru ASADA | Specially Appointed Professor, Osaka University / Vice-President, International Professional University of Technology in Osaka | |
| Hideki NAKANO | Associate Professor, Kyoto Tachibana University | |
| Co-investigators | Hirotaka ONOE | Project Professor, Kyoto University |
| Satoko KOGANEMARU | Program-specific Associate Professor, Kyoto University | |
| Reona YAMAGUCHI | Project Assistant Professor, Kyoto University | |
| Ryo SASAKI | Assistant Professor, Kyoto University | |
| Atsushi SHIMA | Project-specific Assistant Professor, Kyoto University | |
| Kazuki TANAKA | Research Assistant, Kyoto University | |
| Satoko UENO | PhD Student, Kyoto University | |
| Masahiro MITSUHASHI | PhD Student, Kyoto University | |
| Kaoru ISA | Technical stuff, Kyoto University | |
| Saya KITAZUME | Graduate Student, Kyoto University | |
| Erika OMAE | Graduate Student, Kyoto University | |
| Yiping SUN | Research Student, Kyoto University | |
| Tomoyo MORITA | Senior Researcher, CiNet | |
| Jihoon PARK | Specially Appointed Assistant Professor, Osaka University Researcher, CiNet |
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| Tomohiko TAKEI | Associate Professor, Tamagawa University | |
| Satoshi HIROSE | Associate Professor, Otemon Gakuin University | |
| Miho MATSUMATA | Assistant Professor, Hiroshima University | |
| Deepa Kamath Kasaragod |
Assistant Professor, Hiroshima University | |
| Takashi HANDA | Assistant Professor, Hiroshima University | |
| Gen MIURA | Graduate Student, Osaka University | |
| Tomoya FURUTA | Graduate Student, Osaka University | |
| Tang Yandi | Graduate Student, Osaka University | |
| Fumino FUJIYAMA | Professor, Hokkaido University | |
| Huyuki KARUBE | Associate Professor, Hokkaido University | |
| Yasuharu HIRAI | Assistant Professor, Doshisya University | |
| Fuko KADONO | Graduate Student, Hokkaido University |